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J Psychiatr Pract. 2007 Mar;13(2):97-105.

Polypharmacy: when is it rational?

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  • 1University of Kansas School of Medicine-Wichita, Clinical Research Institute, Wichita, KS 67211, USA.


In this article, the authors discuss when it makes sense to consider using more than one medication to treat a single condition. They give a brief history of the use of polypharmacy in psychiatry and discuss how new discoveries in psychotropic drug development are making polypharmacy an increasingly important topic today. The authors then present a list of 10 criteria to guide the rational use of psychotropic polypharmacy and explain each in detail with examples drawn from clinical practice.

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