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Ann N Y Acad Sci. 2007 Feb;1097:171-4.

Role of aerobic fitness and aging on cerebral white matter integrity.

Author information

1
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA. marks@email.unc.edu

Abstract

Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigations of cognitive functioning suggest that some aspects of cognition may be better preserved in older adults who possess higher levels of aerobic fitness. There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions.

PMID:
17413020
DOI:
10.1196/annals.1379.022
[Indexed for MEDLINE]

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