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Science. 2007 Apr 6;316(5821):112-5.

A single IGF1 allele is a major determinant of small size in dogs.

Author information

  • 1National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892-8000, USA.

Erratum in

  • Science. 2007 Jun 1;316(5829):1284.

Abstract

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

PMID:
17412960
PMCID:
PMC2789551
DOI:
10.1126/science.1137045
[PubMed - indexed for MEDLINE]
Free PMC Article
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