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Respir Med. 2007 Aug;101(8):1770-8. Epub 2007 Apr 5.

Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma.

Author information

1
Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E. 7th St, HPER 112, Bloomington, IN 47401, USA.

Abstract

BACKGROUND:

Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects.

OBJECTIVE:

Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB).

METHODS:

Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9alpha, 11beta-prostagladin (PG) F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period.

RESULTS:

The ascorbic acid diet significantly reduced (p < 0.05) the maximum fall in post-exercise FEV1 (-6.4 +/- 2.4%) compared to usual (-14.3 +/- 1.6%) and placebo diet (-12.9 +/- 2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9alpha, 11beta-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet.

CONCLUSION:

Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects.

PMID:
17412579
DOI:
10.1016/j.rmed.2007.02.014
[Indexed for MEDLINE]
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