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J Chromatogr A. 2007 Jun 8;1152(1-2):41-53. Epub 2007 Mar 12.

Selective sample treatment using molecularly imprinted polymers.

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  • 1Laboratoire Environnement et Chimie Analytique (UMR CNRS 7121), Ecole SupĂ©rieure de Physique et de Chimie Industrielles, 10 rue Vauquelin, 75231 Paris Cedex 05, France. valerie.pichon@espci.fr

Abstract

The molecularly imprinted polymers (MIPs) are synthetic polymers possessing specific cavities designed for a target molecule. By a mechanism of molecular recognition, the MIPs are used as selective sorbents for the solid-phase extraction of target analytes from complex matrices. MIPs are often called synthetic antibodies in comparison with immuno-based sorbents; they offer some advantages including easy, cheap and rapid preparation and high thermal and chemical stability. This review describes the use of MIPs in solid-phase extraction with emphasis on their synthesis, the various parameters affecting the selectivity of the extraction, their potential to selectively extract analytes from complex aqueous samples or organic extracts, their on-line coupling with LC and their potential in miniaturized devices.

PMID:
17412351
DOI:
10.1016/j.chroma.2007.02.109
[PubMed - indexed for MEDLINE]
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