Format

Send to

Choose Destination
J Aerosol Med. 2007;20 Suppl 1:S59-63; discussion S63-5.

Facemasks and aerosol delivery by metered dose inhaler-valved holding chamber in young children: a tight seal makes the difference.

Author information

1
Department of Pediatric Pulmonology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands. H.Janssens@erasmusmc.nl

Abstract

A facemask on a valved holding chamber (VHC) facilitates the inhalation of aerosols from metered dose inhalers (MDI) for young children. Only recently the facemask has been recognized as a vital part for efficient aerosol delivery. Several in vitro and in vivo studies show that a tight seal of the facemask is crucial for optimal aerosol deposition to the lungs. Even a small leak can reduce the dose delivered to the lungs considerably. However, a tight seal is difficult to obtain when a child is not cooperative. Depending on the design of the facemask, it is easier to obtain a good seal. Factors such as dead space, shape, and material should be considered when designing a facemask. However, when a child is upset and not cooperative during the administration, aerosol deposition will be minimal, even with the best-designed facemask.

PMID:
17411407
DOI:
10.1089/jam.2007.0578
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center