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Biol Pharm Bull. 2007 Apr;30(4):795-7.

Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus.

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Pharmacology Research Center, Korea Research Institute of Chemical Technology, Korea.


Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC50 values of 1.92, 0.53, and 1.99 microg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.

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