Format

Send to

Choose Destination
See comment in PubMed Commons below
Genetics. 2007 Jun;176(2):999-1011. Epub 2007 Apr 3.

Temporal dynamics and linkage disequilibrium in natural Caenorhabditis elegans populations.

Author information

1
Institut Jacques Monod, CNRS-Universities of Paris 6 and 7, 75251 Paris Cedex 05, France.

Abstract

Caenorhabditis elegans is a major laboratory model system yet a newcomer to the field of population genetics, and relatively little is known of its biology in the wild. Recent studies of natural populations at a single time point revealed strong spatial population structure and suggested that these populations may be very dynamic. We have therefore studied several natural C. elegans populations over time and genotyped them at polymorphic microsatellite loci. While some populations appear to be genetically stable over the course of observation, others seem to go extinct, with full replacement of multilocus genotypes upon regrowth. The frequency of heterozygotes indicates that outcrossing occurs at a mean frequency of 1.7% and is variable between populations. However, in genetically stable populations, linkage disequilibrium between different chromosomes can be maintained over several years at a level much higher than expected from the heterozygote frequency. C. elegans seems to follow metapopulation dynamics, and the maintenance of linkage disequilibrium despite a low yet significant level of outcrossing suggests that selection may act against the progeny of outcrossings.

PMID:
17409084
PMCID:
PMC1894625
DOI:
10.1534/genetics.106.067223
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center