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Microbes Infect. 2007 Apr;9(5):623-8. Epub 2007 Feb 21.

Tumor necrosis factor is critical to control tuberculosis infection.

Author information

1
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Abstract

Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis.

PMID:
17409008
DOI:
10.1016/j.micinf.2007.02.002
[Indexed for MEDLINE]

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