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Neuron. 2007 Apr 5;54(1):121-36.

Cerebellar LTD and pattern recognition by Purkinje cells.

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1
Laboratory of Theoretical Neurobiology, University of Antwerp, B 2610 Antwerp, Belgium. v.steuber@herts.ca.uk

Abstract

Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD. In vivo, we observed longer pauses in LTD-deficient mice. Our results suggest a novel form of neural coding in the cerebellar cortex.

PMID:
17408582
PMCID:
PMC1885969
DOI:
10.1016/j.neuron.2007.03.015
[Indexed for MEDLINE]
Free PMC Article
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