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J Clin Invest. 2007 Apr;117(4):862-5.

HIF-1 and HIF-2: working alone or together in hypoxia?

Author information

1
Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. pjr@well.ox.ac.uk

Abstract

Erythropoietin (EPO) is the hormonal regulator of red cell production and provided the paradigm for oxygen-regulated gene expression that led to the discovery of hypoxia-inducible factor (HIF). In this issue of the JCI, Rankin and colleagues show, using targeted gene inactivation, that induction of Epo expression in murine liver is dependent on the integrity of HIF-2alpha, and not HIF-1alpha (see the related article beginning on page 1068). These results demonstrate distinct functions for different HIF-alpha isoforms that could potentially be exploited in therapeutic approaches to anemia.

PMID:
17404612
PMCID:
PMC1838952
DOI:
10.1172/JCI31750
[Indexed for MEDLINE]
Free PMC Article

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