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J Clin Invest. 2007 Apr;117(4):850-8.

Sickle cell disease: old discoveries, new concepts, and future promise.

Author information

1
Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA.

Abstract

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

PMID:
17404610
PMCID:
PMC1838946
DOI:
10.1172/JCI30920
[Indexed for MEDLINE]
Free PMC Article

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