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Biomacromolecules. 2007 May;8(5):1580-6. Epub 2007 Apr 3.

Rheology of gastric mucin exhibits a pH-dependent sol-gel transition.

Author information

1
Department of Physics, Boston University, Boston, Massachusetts 02215, USA.

Abstract

Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.

PMID:
17402780
DOI:
10.1021/bm0609691
[Indexed for MEDLINE]

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