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Planta Med. 1982 Apr;44(4):207-11.

Phthalides in the essential oil from roots of Levisticum officinale.

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Department of Pharmacognosy, State University of Leiden, Gorlaeus Laboratories, Leiden, The Netherlands.


The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustilide, senkyunolide and validene-4,5-dihydrophthalide were found to be present; isosenkyunolide and propylidenephthalide were tentatively identified. The influence of the isolation procedure on the composition of the phthalide mixture was tentatively studied by comparison of mixtures isolated by solvent extraction and hydrodistillation respectively.


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