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J Neural Transm (Vienna). 2007;114(8):1065-8. Epub 2007 Mar 31.

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression.

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1
Medical School, University of Tampere, Tampere, Finland. samia@koti.soon.fi

Abstract

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

PMID:
17401528
DOI:
10.1007/s00702-007-0705-9
[Indexed for MEDLINE]
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