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Semin Immunol. 2007 Jun;19(3):140-52. Epub 2007 Apr 2.

Molecular mechanisms for adaptive tolerance and other T cell anergy models.

Author information

1
National Institutes of Health, LCMI, NIAID, Bethesda, MD 20892-0420, USA.

Abstract

Since the original description of T cell anergy in CD4 clones from mice and humans, a number of different unresponsive states have been described, both in vivo and in vitro, that have been called anergic. While initial attempts were made to understand the similarities between the different models, it has now become clear from biochemical experiments that many of them have different molecular mechanisms underlying their unresponsiveness. In this review we will detail our own work on the in vivo model referred to as adaptive tolerance and then attempt to compare this biochemical state to the multitude of other states that have been described in the literature.

PMID:
17400472
PMCID:
PMC2045643
DOI:
10.1016/j.smim.2007.02.005
[Indexed for MEDLINE]
Free PMC Article

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