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Hum Immunol. 2007 Apr;68(4):272-6. Epub 2007 Feb 20.

Application of human leukocyte antigen-G expression in the diagnosis of human cancer.

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Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.


It has been well known that human leukocyte antigen (HLA)-G molecules are present in a variety of human neoplastic diseases, and the molecule may contribute to the escape of tumor cells from immune surveillance. Besides the studies that aim at elucidating the roles of HLA-G in immune regulation, the researches that focus on potential applications of HLA-G expression in cancer diagnosis represent another perspective in HLA-G research. This review summarizes those recent translational studies of HLA-G expression in the diagnosis of human cancer. Specifically, the promises and challenges for applying HLA-G expression to detect cancer in body fluids, to diagnose different types of human cancer and to predict clinical outcome in cancer patients will be briefly reviewed.

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