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Phytochemistry. 2007 Apr;68(8):1172-8. Epub 2007 Mar 30.

Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.

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1
Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA.

Abstract

The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.

PMID:
17399748
DOI:
10.1016/j.phytochem.2007.02.021
[Indexed for MEDLINE]
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