Format

Send to

Choose Destination
Semin Immunol. 2007 Aug;19(4):216-24. Epub 2007 Mar 29.

Polyspecificity of T cell and B cell receptor recognition.

Author information

1
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. kai_wucherpfennig@dfci.harvard.edu

Abstract

A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes.

PMID:
17398114
PMCID:
PMC2034306
DOI:
10.1016/j.smim.2007.02.012
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center