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Breast Cancer Res. 2007;9(2):206.

Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine.

Author information

1
Genome Institute of Singapore, Singapore. millerL@gis.a-star.edu

Abstract

Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered transcriptional architecture. Comprising this architecture are gene expression networks, or signatures, reflecting biochemical and behavioral properties of tumors that might be harnessed to improve disease subtyping, patient prognosis and prediction of therapeutic response. Emerging 'hypothesis-driven' strategies that incorporate knowledge of pathways and other biological phenomena in the signature discovery process are linking prognosis and therapy prediction with transcriptional readouts of tumorigenic mechanisms that better inform therapeutic options.

PMID:
17397520
PMCID:
PMC1868923
DOI:
10.1186/bcr1662
[Indexed for MEDLINE]
Free PMC Article

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