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Science. 2007 Apr 27;316(5824):597-600. Epub 2007 Mar 29.

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.

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Division of Biology, Mail Code 156-29, California Institute of Technology, Pasadena, CA 91125, USA.


One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.

10.1126/science. 1138595
[Indexed for MEDLINE]
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