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Drug Discov Today. 2007 Apr;12(7-8):314-8. Epub 2007 Mar 7.

Research & market strategy: how choice of drug discovery approach can affect market position.

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  • 1Bionomics Ltd. Europe, Rue Jean Sapidus, Parc d'Innovation, F-67400 Illkirch, France.


In principal, drug discovery approaches can be grouped into target- and function-based, with the respective aims of developing either a target-selective drug or a drug that produces a specific biological effect irrespective of its mode of action. Most analyses of drug discovery approaches focus on productivity, whereas the strategic implications of the choice of drug discovery approach on market position and ability to maintain market exclusivity are rarely considered. However, a comparison of approaches from the perspective of market position indicates that the functional approach is superior for the development of novel, innovative treatments.

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