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Immunol Today. 1992 Jan;13(1):11-6.

The immune system evolved to discriminate infectious nonself from noninfectious self.

Author information

1
Section of Immunobiology, Yale University, New Haven, CT.

Abstract

Here, Charles Janeway argues that the requirement for two signals to initiate the adaptive immune response may reflect the evolutionary history of host defences. Early phases of host defence involve receptors and ligands that may have controlled immune responses prior to the development of clonally-distributed receptors encoded in rearranging genes. The former receptors persist in contemporary vertebrates both to trigger innate or nonclonal responses and to signal to lymphocytes that a particular antigen is associated with a microorganism.

PMID:
1739426
DOI:
10.1016/0167-5699(92)90198-G
[Indexed for MEDLINE]

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