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Br J Cancer. 2007;96 Suppl:R21-5.

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE.

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Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.


In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.


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