Format

Send to

Choose Destination
See comment in PubMed Commons below
Microsc Res Tech. 2007 May;70(5):398-402.

Clinical two-photon microendoscopy.

Author information

1
Fraunhofer Institute of Biomedical Technology (IBMT), St. Ingbert, Saarland, Germany. karsten.koenig@ibmt.fraunhofer.de

Abstract

Two-photon medical imaging has found its way into dermatology as an excellent method for noninvasive skin cancer detection without need of contrast agents as well as for in situ drug screening of topically-applied cosmetical and pharmaceutical components. There is an increasing demand to apply the multiphoton technology also for deep-tissue skin imaging as well as for intracorporal imaging. We report on the first clinical use of multiphoton endoscopes, in particular of a miniaturized rigid two-photon GRIN lens endoscope. The microendoscope was attached to the multiphoton tomograph DermaInspect and employed to detect the extracellular matrix proteins collagen and elastin in the human dermis of volunteers and patients with ulcera by in vivo second harmonic generation and in vivo two-photon autofluorescence.

PMID:
17393493
DOI:
10.1002/jemt.20445
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Loading ...
    Support Center