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J Invest Dermatol. 2007 Aug;127(8):1883-5. Epub 2007 Mar 29.

Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses.

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Department of Dermatology, University of Regensburg, Regensburg, Germany.


Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.

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