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J Invest Dermatol. 2007 Aug;127(8):1883-5. Epub 2007 Mar 29.

Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses.

Author information

1
Department of Dermatology, University of Regensburg, Regensburg, Germany. christian.hafner@klinik.uni-regensburg.de

Abstract

Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.

PMID:
17392824
DOI:
10.1038/sj.jid.5700804
[Indexed for MEDLINE]
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