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Med Sci Monit. 2007 Apr;13(4):CR195-200.

Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer.

Author information

1
Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey. kadir@atauni.edu.tr

Abstract

BACKGROUND:

Lung cancer is the leading cause of cancer death in both developed and developing countries. The aim of the present study was to compare serum levels of alpha1-acid glycoprotein, ceruloplasmin, transferrin, ferritin, and albumin with tumor stage, distant metastasis, lymphadenopa thy, and patient performance status in patients with non-small-cell lung cancer and those with small-cell lung cancer.

MATERIAL/METHODS:

The study was carried out in 46 patients with primary lung cancer (39 men and 7 women) and 34 healthy subjects as the control group.

RESULTS:

Serum ceruloplasmin and ferritin levels were higher and transferrin and albumin levels were lower both in non-small-cell and small-cell lung cancer patients than in controls. The levels of alpha1-acid glycoprotein and ferritin associated with both performance status and lymph node metastasis.

CONCLUSIONS:

Measurement of alpha1-acid glycoprotein and ferritin levels could be a useful prognostic factor in addition to performance status in patient with primary lung cancer.

PMID:
17392651
[Indexed for MEDLINE]

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