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Med Sci Monit. 2007 Apr;13(4):CR195-200.

Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer.

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Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey.



Lung cancer is the leading cause of cancer death in both developed and developing countries. The aim of the present study was to compare serum levels of alpha1-acid glycoprotein, ceruloplasmin, transferrin, ferritin, and albumin with tumor stage, distant metastasis, lymphadenopa thy, and patient performance status in patients with non-small-cell lung cancer and those with small-cell lung cancer.


The study was carried out in 46 patients with primary lung cancer (39 men and 7 women) and 34 healthy subjects as the control group.


Serum ceruloplasmin and ferritin levels were higher and transferrin and albumin levels were lower both in non-small-cell and small-cell lung cancer patients than in controls. The levels of alpha1-acid glycoprotein and ferritin associated with both performance status and lymph node metastasis.


Measurement of alpha1-acid glycoprotein and ferritin levels could be a useful prognostic factor in addition to performance status in patient with primary lung cancer.

[Indexed for MEDLINE]

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