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Int J Biochem Cell Biol. 2007;39(11):1999-2005. Epub 2007 Jan 20.

Arylamine N-acetyltransferase I.

Author information

1
School of Biomedical Sciences, University of Queensland, Queensland, Australia. r.minchin@uq.edu.au

Abstract

Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and shares homology to NAT genes found in most mammalian species. Gene expression occurs from at least two promoters and a number of tissue-specific transcripts have been identified. The gene is polymorphic with most mutations identified to date producing an unstable protein that is subject to polyubiquitination. The NAT1 protein contains a catalytic triad similar to a number of cysteine proteases and transglutaminases. NAT1 is widely distributed in the body, but the only endogenous substrate identified to date is the folate catabolite p-aminobenzoylglutamate. Recent links between NAT1 genotypes and susceptibility to spina bifida suggests that the enzyme has an important role in folate homeostasis.

PMID:
17392017
DOI:
10.1016/j.biocel.2006.12.006
[Indexed for MEDLINE]

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