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Eur Neurol. 2007;57(4):232-5. Epub 2007 Mar 26.

Statins provoking MELAS syndrome. A case report.

Author information

1
Department of Internal Medicine, School of Medicine, University of Connecticut, Farmington, Conn., USA. drjethomas@yahoo.com

Abstract

BACKGROUND:

Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy.

METHODS:

We present the case of a patient with mitochondrial syndrome, consisting of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), whose symptoms were temporally related to statin therapy.

CONCLUSION:

Statins may provoke symptoms related to MELAS in susceptible individuals.

PMID:
17389800
DOI:
10.1159/000101287
[Indexed for MEDLINE]

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