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Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6436-41. Epub 2007 Mar 26.

The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds.

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1
Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Abstract

ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and the mechanism of, its release have not been identified. Using CHO cells expressing high-affinity neurotransmitter receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds. ATP further stimulates other taste cells to release a second transmitter, serotonin. These results provide a mechanism to link intracellular Ca(2+) release during taste transduction to secretion of afferent transmitter, ATP, from receptor cells. They also indicate a route for cell-cell communication and signal processing within the taste bud.

PMID:
17389364
PMCID:
PMC1851090
DOI:
10.1073/pnas.0611280104
[Indexed for MEDLINE]
Free PMC Article
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