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Diabetes Care. 2007 Jul;30(7):1730-5. Epub 2007 Mar 27.

Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes: the Nurses' Health Study.

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  • 1Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. janghorbani@yahoo.com

Abstract

OBJECTIVE:

The aim of this study was to examine the relationship between type 1 and type 2 diabetes and risk of stroke subtypes in women.

RESEARCH DESIGN AND METHODS:

We followed 116,316 women aged 30-55 years in 1976 through 2002 for incidence of stroke. At baseline and through biennial follow-up, women were asked about their history and treatment of diabetes and other potential risk factors for stroke.

RESULTS:

During 2.87 million person-years of follow-up, 3,463 incident strokes occurred. In multivariate analyses, the incidence of total stroke was fourfold higher in women with type 1 diabetes (relative risk [RR] 4.7 [95% CI 3.3-6.6]) and twofold higher among women with type 2 diabetes (1.8 [1.7-2.0]) than for nondiabetic women. The multivariate RR of ischemic stroke was increased sixfold (6.3 [4.0-9.8]) in type 1 diabetes and twofold (2.3 [2.0-2.6]) in type 2 diabetes. Risks for large-artery infarction and lacunar stroke were similar. Type 1 diabetes was also significantly associated with the risk of hemorrhagic stroke (3.8 [1.2-11.8]), but type 2 diabetes was not (1.0 [0.7-1.4]).

CONCLUSIONS:

Both type 1 and type 2 diabetes are associated with substantially increased risks of total and most subtypes of stroke.

PMID:
17389335
DOI:
10.2337/dc06-2363
[PubMed - indexed for MEDLINE]
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