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Neurology. 2007 Mar 27;68(13):1045-50.

Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis.

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Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, Italy.



To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity.


We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity.


A single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation.


Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis.

[Indexed for MEDLINE]

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