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Soc Cogn Affect Neurosci. 2006 Jun;1(1):65-71.

rTMS to the right inferior parietal lobule disrupts self-other discrimination.

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1
Department of Psychology, University of California, Los Angeles, 90095, USA. lucina@ucla.edu

Abstract

Self-other discrimination is fundamental to social interaction, however, little is known about the neural systems underlying this ability. In a previous functional magnetic resonance imaging study, we demonstrated that a right fronto-parietal network is activated during viewing of self-faces as compared with the faces of familiar others. Here we used image-guided repetitive transcranial magnetic stimulation (rTMS) to create a 'virtual lesion' over the parietal component of this network to test whether this region is necessary for discriminating self-faces from other familiar faces. The current results indeed show that 1 Hz rTMS to the right inferior parietal lobule (IPL) selectively disrupts performance on a self-other discrimination task. Applying 1 Hz rTMS to the left IPL had no effect. It appears that activity in the right IPL is essential to the task, thus providing for the first time evidence for a causal relation between a human brain area and this high-level cognitive capacity.

PMID:
17387382
PMCID:
PMC1832105
DOI:
10.1093/scan/nsl003
[Indexed for MEDLINE]
Free PMC Article
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