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Thorax. 2007 Apr;62(4):360-7.

Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis.

Author information

1
Department of Medicine, University of Washington Medical Center, Campus Box 356522, 1959 NE Pacific, Seattle, Washington 98195, USA. goss@u.washington.edu

Abstract

With the improving survival of patients with cystic fibrosis (CF), the clinical spectrum of this complex multisystem disease continues to evolve. One of the most important clinical events for patients with CF in the course of this disease is an acute pulmonary exacerbation. Clinical and microbial epidemiology studies of CF pulmonary exacerbations continue to provide important insight into the course, prognosis and complications of the disease. This review provides a summary of the pathophysiology, clinical epidemiology and microbial epidemiology of a CF pulmonary exacerbation.

PMID:
17387214
PMCID:
PMC2092469
DOI:
10.1136/thx.2006.060889
[Indexed for MEDLINE]
Free PMC Article
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