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Mol Cell. 2007 Mar 23;25(6):796-7.

On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor.

Author information

1
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA.

Abstract

In a recent issue of Molecular Cell, Yu et al. (2007) reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytoplasmic function: it activates the translational silencers TIA-1 and TIAR and thus inhibits the translation of proinflammatory cytokines.

PMID:
17386257
DOI:
10.1016/j.molcel.2007.03.005
[Indexed for MEDLINE]
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