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Org Lett. 2007 Apr 26;9(9):1691-4. Epub 2007 Mar 27.

One-pot, multicomponent route to pyrazoloquinolizinones.

Author information

1
State Scientific Institution "Institute for Single Crystals" of the National Academy of Sciences of Ukraine, Lenin Ave, Kharkiv, Ukraine.

Abstract

[reaction: see text] An efficient synthesis of 5a-hydroxy-4,5,5a,6,7,8-hexahydropyrazolo[4,3-c]quinolizin-9-ones based on the three-component condensation of 5-aminopyrazoles, aromatic aldehydes, and cyclic 1,3-diketones is described. The multicomponent reaction is performed under strongly basic conditions applying controlled microwave heating in a sealed vessel and involves an unusual base-mediated ring-opening/recyclization of the cyclic 1,3-diketone moiety.

PMID:
17385876
DOI:
10.1021/ol070411l
[Indexed for MEDLINE]

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