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Nat Struct Mol Biol. 2007 Apr;14(4):349-50. Epub 2007 Mar 25.

The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated.

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1
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-8656, Japan.

Abstract

Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs tested are fully modified by 2'-O-methylation at their 3' termini. This observation may provide a clue to the biogenesis and function of piRNAs in spermatogenesis.

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PMID:
17384646
DOI:
10.1038/nsmb1220
[Indexed for MEDLINE]
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