Format

Send to

Choose Destination
Life Sci. 2007 May 30;80(24-25):2347-51. Epub 2007 Feb 17.

Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor.

Author information

1
Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Drive, Falk CVRC, Stanford CA 94305-5406, United States. john.cooke@stanford.edu

Abstract

An endothelial nicotinic acetycholine receptor (nAChR) mediates endothelial proliferation, survival, migration and tube formation in vitro, and angiogenesis in vivo. Exogenous nicotine stimulates this angiogenic pathway. This action of nicotine may contribute to tumor angiogenesis and tumor growth; atherosclerotic plaque neovascularization and progression; and other tobacco-related diseases. The endothelial nAChR mediates an angiogenic pathway that is interdependent with growth factor mediated pathways, as shown by pharmacological and molecular studies. The characterization of this new angiogenic pathway may provide a new therapeutic avenue for disorders of insufficient or pathological angiogenesis.

PMID:
17383685
PMCID:
PMC1941778
DOI:
10.1016/j.lfs.2007.01.061
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center