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Curr Opin Microbiol. 2007 Apr;10(2):182-8. Epub 2007 Mar 23.

Small noncoding RNAs controlling pathogenesis.

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Institut Pasteur, Unité des Interactions Bactéries-Cellules, INSERM, U604, and INRA, USC2020, Paris, F-75015, France.


Infectious diseases are a leading cause of mortality worldwide. A major challenge in achieving their eradication is a better understanding of bacterial pathogenesis processes. The recent discovery of small noncoding RNAs (sRNAs) as modulators of gene expression in response to environmental cues has brought a new insight into bacterial regulation. sRNAs coordinate complex networks of stress adaptation and virulence gene expression. sRNAs generally ensure such a regulation by pairing to mRNAs of effector and/or regulatory genes, or by binding to proteins. An updated view on bacterial models responsible for important infections illustrates the key role of sRNAs in the control of pathogenesis.

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