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Presse Med. 2007 May;36(5 Pt 1):808-9. Epub 2007 Mar 23.

Familial occurrence of painful subacute thyroiditis associated with human leukocyte antigen-B35.

Author information

1
Internal medicine and infectious diseases department, Saint-Joseph Hospital and Medical Center, Dora, Lebanon. dremilezein2000@yahoo.com

Abstract

INTRODUCTION:

Subacute thyroiditis (SAT) is a spontaneously remitting inflammatory disorder of the thyroid that is presumed to be virally induced in genetically predisposed individuals. A strong association has been suggested between human leukocyte antigen (HLA)-B35 and patients who developed SAT. However, familial occurrence of SAT associated with HLA-B35 is reported only rarely.

CASE-REPORTS:

We report three sibs, (two brothers and one sister) living in the same Lebanese town, who developed SAT during an 18-month-period. All tested positive for HLA-B35.

DISCUSSION:

The family described here represents the first Third World third familial report of SAT associated with HLA-B35. It highlights the probably underestimated importance of genetic predisposition to SAT in families.

PMID:
17383147
DOI:
10.1016/j.lpm.2007.02.011
[Indexed for MEDLINE]
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