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J Pediatr. 2007 Apr;150(4):383-7.

Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children.

Author information

1
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison 53792, USA. dballen@wisc.edu

Abstract

OBJECTIVE:

We studied the relationship between % body fat (%BF), cardiovascular fitness (CVF), and insulin resistance (IR) in overweight middle-school children.

STUDY DESIGN:

Middle school children (n = 106, body mass index [BMI] > 95th percentile for age) underwent evaluation of body composition, maximal volume of oxygen utilization (VO2) uptake/kg lean body mass (VO2max/kgLBM), and fasting glucose and insulin (FI) concentrations and derived homeostasis model assessment index (HOMA(IR)).

RESULTS:

Both %BF (r = .33, P < .001) and VO2max/kgLBM (r = -0.42, P < .0001) were significantly correlated with FI. Bivariate regression analysis revealed %BF (P = .008 vs FI, P = .035 vs HOMA(IR)) and VO2max/kgLBM (P < .001 vs FI, P = .009 vs HOMA(IR)) to be independent predictors of insulin sensitivity. In males, VO2max/kgLBM was a better predictor of FI and HOMA(IR) than %BF.

CONCLUSIONS:

In obese middle-school children, both %BF and VO2max/kgLBM are independent predictors of FI levels. The relationship between CVF and FI levels was significant in both sexes but was particularly profound and stronger than %BF in males. Efforts to reduce risk of type 2 diabetes mellitus in an increasingly obese child population should include exercise intervention sustained enough to improve CVF.

PMID:
17382115
DOI:
10.1016/j.jpeds.2006.12.051
[Indexed for MEDLINE]

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