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J Pediatr. 2007 Apr;150(4):370-5, 375.e1.

Decreased adult height in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.

Author information

1
Department of Pediatrics, University of Washington, Seattle, Washington, USA. ericchow@u.washington.edu

Abstract

OBJECTIVE:

To determine risk factors associated with reduced adult height in survivors of childhood acute lymphoblastic leukemia (ALL).

STUDY DESIGN:

This was a cross-sectional study. Attained adult height was determined among 2434 ALL survivors participating in the Childhood Cancer Survivor Study, a cohort of 5-year survivors of common pediatric cancers diagnosed from 1970 to 1986, and compared with 3009 siblings.

RESULTS:

All survivor treatment exposure groups (chemotherapy alone, chemotherapy with cranial or craniospinal radiotherapy) had decreased adult height and an increased risk of adult short stature (height standard deviation score < -2) compared with siblings (P < .001). Compared with siblings, the risk of short stature for survivors treated with chemotherapy alone was elevated (OR, 3.4; 95% CI, 1.9, 6.0). Among survivors, significant risk factors for short stature included diagnosis of ALL before puberty, higher-dose cranial radiotherapy (> or = 20 Gy versus < 20 Gy), any radiotherapy to the spine, and female sex.

CONCLUSIONS:

Survivors of childhood ALL are at increased risk of adult short stature, including those treated with chemotherapy alone. Risk is highest for those treated with cranial and craniospinal radiotherapy at a young age.

PMID:
17382112
PMCID:
PMC2766352
DOI:
10.1016/j.jpeds.2006.11.036
[Indexed for MEDLINE]
Free PMC Article

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