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Mol Med. 2006 Nov-Dec;12(11-12):284-90.

Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation.

Author information

1
Laboratory of Experimental Immunology, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, USA. dmessmer@ucsd.edu

Abstract

We evaluated the effect of morphine on human dendritic cells (DCs). Interestingly, immature DCs were found to express all 3 (mu, kappa, delta) opioid receptors on the cell surface. Chronic morphine treatment (10(-8) to 10(-12) M) during the development of DCs from monocytes augmented LPS-induced upregulation of HLA-DR, CD86, CD80, and CD83 and increased the T cell stimulatory capacity of DCs, which could be inhibited by naloxone, an opioid receptor antagonist. The change in surface phenotype was paralleled by a p38 MAPK-dependent decrease in IL-10 and increase in IL-12 secretion. Our data indicate that morphine exerts an immunostimulatory effect by modulating LPS-induced DC maturation.

PMID:
17380193
PMCID:
PMC1829197
DOI:
10.2119/2006–00043.Messmer
[Indexed for MEDLINE]
Free PMC Article

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