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Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83.

p53 in health and disease.

Author information

1
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK. k.vousden@beatson.gla.ac.uk

Abstract

As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism. Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life.

PMID:
17380161
DOI:
10.1038/nrm2147
[Indexed for MEDLINE]

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