Send to

Choose Destination
Nat Rev Immunol. 2007 Apr;7(4):305-10.

FOXP3 modifies the phenotypic and functional properties of regulatory T cells.

Author information

Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA.


In the periphery, tolerance to self antigens is mainly mediated by the CD4(+)CD25(+)FOXP3(+) subset of regulatory T cells, which can suppress the activity of autoreactive T cells that have escaped deletion in the thymus. The essential role of the transcription factor FOXP3 (forkhead box P3) in the development and function of these regulatory T cells has been well documented. It is also clear that regulatory T cells and effector T cells respond differently to T-cell receptor stimulation. In this Opinion article, we propose that these differences in responses are mediated by FOXP3, and are manifested by alterations in biochemical signalling pathways, patterns of gene expression and the appearance of cell-surface homing receptors.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center