Format

Send to

Choose Destination
Biochimie. 2007 Jun-Jul;89(6-7):754-60. Epub 2007 Feb 20.

Triggering antiviral response by RIG-I-related RNA helicases.

Author information

1
Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. tfujita@virus.kyoto-u.ac.jp

Abstract

TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.

PMID:
17379377
DOI:
10.1016/j.biochi.2007.01.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center