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J Allergy Clin Immunol. 2007 May;119(5):1079-85. Epub 2007 Mar 26.

Is the prevalence of wheeze in children altered by neonatal BCG vaccination?

Author information

1
General Practice Research Unit, North West Lung Research Centre, Wythenshawe Hospital, Manchester. linehanmary@yahoo.co.uk

Abstract

BACKGROUND:

The prevalence of asthma and atopic disease has increased in recent decades, but precise reasons for this increase are unknown. BCG vaccination is thought to be among a group of vaccines capable of manipulating the immune system toward T(H)1 dominance and therefore reducing the likelihood of atopic disease.

OBJECTIVE:

The aim of this study was to determine the influence of neonatal BCG vaccination on the prevalence of wheeze in a large community population of children.

METHOD:

In a historical cohort study, a parent-completed questionnaire was used to identify the prevalence of wheeze in BCG-vaccinated and nonvaccinated children in Manchester, England.

RESULTS:

There were 2414 participants aged between 6 and 11 years. In a univariate analysis neonatal BCG vaccination was associated with a significantly lower prevalence of wheeze (odds ratio, 0.69; 95% CI, 0.55-0.86), and statistical significance was retained when the analysis was adjusted for potential confounders (odds ratio, 0.68; 95% CI, 0.53-0.87).

CONCLUSION:

These results demonstrate an association between asthma symptom prevalence and neonatal BCG vaccination, relating to a possible 27% reduction in prevalence, and are therefore of considerable public health importance.

CLINICAL IMPLICATIONS:

The capacity of neonatal BCG vaccination to reduce the prevalence of respiratory symptoms in children warrants further investigation.

PMID:
17379292
DOI:
10.1016/j.jaci.2006.12.672
[Indexed for MEDLINE]
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