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Nat Rev Mol Cell Biol. 2007 May;8(5):405-13. Epub 2007 Mar 21.

The apoptosome: signalling platform of cell death.

Author information

1
Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. sriedl@burnham.org

Abstract

Recent work on the initial switches that trigger cell death has revealed surprising inventions of nature that ensure the ordered suicide of a cell that has been selected for demise. Particularly intriguing is how a signal--the release of cytochrome c from the mitochondria--is translated into the activation of the death cascade, which leads to a point of no return. Now there is new understanding of how this crucial process is delicately handled by a cytosolic signalling platform known as the apoptosome. The formation of the apoptosome and the activation of its effector, caspase-9, reveals a sophisticated mechanism that might be more common than was initially thought.

PMID:
17377525
DOI:
10.1038/nrm2153
[Indexed for MEDLINE]

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