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J Vasc Interv Radiol. 2007 Mar;18(3):419-25.

Thrombus formation at the surface of guide-wire models: effects of heparin-releasing or heparin-exposing surface coatings.

Author information

1
Centre for Biomaterials Research, Faculty of Medicine, University of Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands. y.aldenhoff@bioch.unimaas.nl

Abstract

PURPOSE:

This study was conducted to investigate whether thrombus formation at the surface of guide wires occurs, and--if so--whether this can be suppressed or prevented through incorporation of heparin in the surface coating.

MATERIALS AND METHODS:

Five guide wire models were examined; three had a polymeric hydrophilic surface coating (90/10 guide wire), which was either heparin-free, impregnated with sodium-heparin (Na-hep), or impregnated with benzalkonium heparin (BAK-hep). The other two guide wires had a coating of polytetrafluoroethylene (PTFE), either without heparin, or impregnated with BAK-hep. Release of heparin, exposure of heparin at the surface of the guide wires, thrombogenicity (under static and flow conditions) and their propensity to attract blood platelets were investigated.

RESULTS:

The guide wire 90/10 Na-hep releases approximately 150-200 mU active heparin per cm coil within the first few minutes after incubation in buffer. The PTFE BAK-hep shows a relatively slow release of 60-70 mU active heparin per cm coil. The 90/10 BAK-hep showed no released heparin but the most exposed heparin. In a static experiment with human full blood excessive thrombus formation occurred at the heparin-free models, whereas the others remained essentially clean. In a thrombin-generation assay under flow the authors observed strong retardation of thrombin formation in the case of the 90/10 Na-hep guide wire.

CONCLUSIONS:

The static and dynamic in vitro assays, taken together, show that the 90/10 Na-hep provides a coating with an extremely low level of surface thrombogenicity. Use of a guide wire with a hydrophilic distal coating that releases and exposes sodium heparin may contribute to the safety of diagnostic and therapeutic interventional procedures.

PMID:
17377189
DOI:
10.1016/j.jvir.2006.12.733
[Indexed for MEDLINE]

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