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Ann N Y Acad Sci. 2007 Apr;1103:192-5. Epub 2007 Mar 21.

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

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Department of Immunohematology and Blood Transfusion, LUMC, E3-Q, P.O. Box 9600, 2300 RC Leiden, the Netherlands.


Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction. However, little is known about the target antigens of CD8(+) T cells in human T1D patients. The aim of this study was to assess whether an epitope derived from the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), IGRP(265-273,) which has recently been identified as a target in non-obese diabetic (NOD) mice and is fully homologous to the human epitope, is a target of human diabetogenic CD8(+) T cells. We isolated a human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species.

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